In another paper published January, 2012, we have produced perhaps some of our most exciting findings to date. Early on inThe New England Centenarian Study, we thought that centenarians had to markedly delay or even escape age-related diseases like heart attacks, stroke, diabetes and Alzheimer’s, or else they would never be able to get to their very old ages. In fact, in 1980, a Stanford researcher named James Fries proposed the “Compression of Morbidity” hypothesis which states that as one approaches the limit of human life span, they must compress the time that they develop diseases towards the very end of their life and he proposed that people around the age of 100 do this. However, in 2003 we found that many of our centenarian subjects had age related diseases even before the age of 80 (about 43%, and whom we called “survivors”), after the age of 80 (about 42% and whom we called “delayers”) and lastly, those who had no mortality-associated diseases at age 100 (about 15% and whom we called escapers). The key though was that 90% of all of the centenarians were still independently functioning at the average age of 93 years. Somehow, despite the presence of diseases, people who become centenarians don’t die from those diseases, but rather they are able to deal with them much better than other people and remain independently functioning more than 30 years beyond the age of 60. Therefore it seemed to us that for these study participants, it was not so much the compression of morbidity that was important to their survival, but rather a compression of disability.
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Saturday, July 22, 2017
The Older You Get, The Healthier You’ve Been
In another paper published January, 2012, we have produced perhaps some of our most exciting findings to date. Early on inThe New England Centenarian Study, we thought that centenarians had to markedly delay or even escape age-related diseases like heart attacks, stroke, diabetes and Alzheimer’s, or else they would never be able to get to their very old ages. In fact, in 1980, a Stanford researcher named James Fries proposed the “Compression of Morbidity” hypothesis which states that as one approaches the limit of human life span, they must compress the time that they develop diseases towards the very end of their life and he proposed that people around the age of 100 do this. However, in 2003 we found that many of our centenarian subjects had age related diseases even before the age of 80 (about 43%, and whom we called “survivors”), after the age of 80 (about 42% and whom we called “delayers”) and lastly, those who had no mortality-associated diseases at age 100 (about 15% and whom we called escapers). The key though was that 90% of all of the centenarians were still independently functioning at the average age of 93 years. Somehow, despite the presence of diseases, people who become centenarians don’t die from those diseases, but rather they are able to deal with them much better than other people and remain independently functioning more than 30 years beyond the age of 60. Therefore it seemed to us that for these study participants, it was not so much the compression of morbidity that was important to their survival, but rather a compression of disability.
Genetic Signatures of Exceptional Longevity in Humans
Genes play a critical and complex role in facilitating exceptional longevity. The genetic influence becomes greater and greater with older and older ages, especially beyond 103 years of age.
Because many genes are involved, one needs to include many different genes at once (rather than one at a time) in what is called a genetic profile to accurately categorize who is a centenarian and who is not, based on genetic data alone.
We found 281 genetic markers that are 61% accurate in predicting who is 100 years old, 73% accurate in predicting who is 102 years old or older and 85% accurate in predicting who is 105 years old or older. In other words the prediction gets better with older and older ages beyond 100 which goes along with our hypothesis that the genetic component of exceptional longevity gets greater and greater with older and older age.
These 281 markers point to at least 130 genes, many of which have been shown to play roles in Alzheimer’s, diabetes, heart disease, cancers, high blood pressure, and basic biological mechanisms of aging.
Centenarians have just as many genetic variants that are associated with increased risk for age-related diseases (like Alzheimer’s, heart disease, stroke, diabetes and cancer) as people in the general population. Therefore, their tremendous survival advantage may in great part be due to the existence of longevity associated genetic variants that are protective and counter the negative effects of such disease gene variants.
People have genetic profiles that can be constructed from these 281 genetic markers (each of which has 3 variations) and these in turn are associated with specific probabilities of achieving very old age. Very interestingly, sub-groups of subjects have genetic profiles in common (what we call genetic signatures). Ninety percent of the 801 centenarians in the New England Centenarian Study could be grouped into one of 27 genetic signatures.
These genetic signatures are also associated with different predispositions to subgroups of centenarians such as those that completely escape heart disease, or those that delay Alzheimer’s disease until the last 5% of their very long lives. This method of generating signatures will be very useful for better understanding the underlying genetics of protection from age-related diseases, modulators of rates of aging and for the field of predictive and precision medicine.
Citation: Genetic Signatures of Exceptional Longevity in Humans. Paola Sebastiani, Nadia Solovieff, Andrew T. DeWan, Kyle M. Walsh, Annibale Puca, Stephen W. Hartley, Efthymia Melista, Stacy Andersen, Daniel A. Dworkis, Jemma B. Wilk, Richard H. Myers, Martin H. Steinberg, Monty Montano, Clinton T. Baldwin, Josephine Hoh, Thomas T. Perls. PloS ONE 2012. DOI: 10.1371/journal.pone.0029848.
Many of the above genetic findings were replicated in a combination of 5 collaborating centenarian studies.
Friday, July 21, 2017
Definition of study for Students
study
1 : to make an effort to learn about something by reading, investigating, or memorizing- 2 : to give close attention to I studied the X-rays as Dr. Cone pointed things out to me. — Judy Blume, Tales of a Fourth Grade Nothing12c., from Old French estudier "to study" (French étude), from Medieval Latin studiare, from Latin studium "study, application," originally "eagerness," from studere "to be diligent" ("to be pressing forward"), from PIE *(s)teu- "to push, stick, knock, beat" (see steep (adj.)). The noun meaning "application of the mind to the acquisition of knowledge" is recorded from c.1300. Sense of "room furnished with books" is from c.1300. Study hall is attested from 1891, originally a large common room in a college. Studious is attested from late 14c.
Synonyms
Recent Examples of study from the Web
- Robertson has pushed to regulate housing more tightly amid a public outcry over the lack of affordable homes for residents despite studies showing that as many as 66,000 dwellings in Vancouver are vacant or temporarily occupied.
- As Schueller noted, that 1990 study indicating a causal link between aluminum and Alzheimer’s was discredited.
- Back in May, the regional supermarket chain won the title for the second year in a row in Market Force Information's annual consumer study of 12,700 shoppers.
Definition of study
studies
- 1: a state of contemplation : reverie
- 2a : application of the mental faculties to the acquisition of knowledge years of studyb : such application in a particular field or to a specific subject the study of Latinc : careful or extended consideration the proposal is under studyd (1) : a careful examination or analysis of a phenomenon, development, or question (2) : the published report of such a study
- 3: a building or room devoted to study or literary pursuits
- 5a : a branch or department of learning : subject —often used in plural American studiesb : the activity or work of a student returning to her studies after vacationc : an object of study or deliberationevery gesture a careful study — Marcia Davenportd : something attracting close attention or examination
- 6: a person who learns or memorizes something (such as a part in a play) —usually used with a qualifying adjective he's a quick study
- 7: a literary or artistic production intended as a preliminary outline, an experimental interpretation, or an exploratory analysis of specific features or characteristics
- 8: a musical composition for the practice of a point of technique
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